Publications by authors named "C Georgelin"

We present in this paper a global methodology for the spike detection in a biological context of fluorescence recording of GnRH-neurons calcium activity. For this purpose we first propose a simple stochastic model that could mimic experimental time series by considering an autoregressive AR(1) process with a linear trend and specific innovations involving spiking times. Estimators of parameters with asymptotic normality are established and used to set up a statistical test on estimated innovations in order to detect spikes.

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Article Synopsis
  • Episodic release of GnRH is crucial for reproductive function, driven by a synchronization of GnRH neuron activity, but the exact mechanisms behind this synchronization are not fully understood.
  • The study investigates the role of glial cell communication via gap junctions in regulating GnRH neuron activity, identifying that glial cells expressing connexin-43 are present near GnRH fibers.
  • Experimental results show that blocking these gap junctions reduces GnRH secretion and disrupts neuronal synchronization, but these effects can be reversed, indicating the importance of glial cells in maintaining GnRH neuron function.
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In this work, the modeling of the digestion in the small intestine is developed by investigating specifically the effects of dietary fiber. As our previous model, this new version takes into account the three main phenomena of digestion: transit of the bolus, degradation of feedstuffs and absorption through the intestinal wall. However the two main physiochemical characteristics of dietary fiber, namely viscosity and water holding capacity, lead us to substantially modify our initial model by emphasizing the role of water and its intricated dynamics with dry matter in the bolus.

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We describe a mathematical model of digestion in the small intestine. The main interest of our work is to consider simultaneously the different aspects of digestion i.e.

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