Publications by authors named "C Genbrugge"
Human organ transplantation has begun in the 1960s with donation after circulatory death. At that time this was named non heart beating donation, later donation after cardiac death and nowadays it is named donation after circulatory death. Currently, we are facing a significant shortage of transplant organs in Europe and worldwide.
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- - The study investigates the potential for injury during chest compressions (CC) on infants and children, comparing two depth targets: 1.5 inches and 1/3 of the anterior-posterior chest diameter (APD), finding that the latter may lead to more severe injuries.
- - Using an anesthetized swine model, researchers induced asphyxia and delivered CC using both depth targets to assess the resulting injuries, with various factors being monitored and analyzed post-resuscitation.
- - Results from 36 animals showed significant differences in injury characteristics between the two compression depths, prompting further evaluation of safe guidelines for pediatric resuscitation practices.
Background: Observation of the electrocardiogram (ECG) immediately following return of spontaneous circulation (ROSC) in resuscitated swine has revealed the interesting phenomenon of sudden ECG rhythm changes (SERC) that occur in the absence of pharmacological, surgical, or other medical interventions.
Objective: We sought to identify, quantify, and characterize post-ROSC SERC in successfully resuscitated swine.
Methods: We reviewed all LabChart data from resuscitated approximately 4- to 6-month-old swine used for various experimental protocols from 2006 to 2019.
Article Synopsis
- These guidelines provide evidence-based recommendations for managing temperature in adults who are comatose following cardiac arrest, replacing earlier 2021 protocols.
- An expert panel reviewed the evidence, using the GRADE approach, to assess the reliability of the recommendations, which highlighted the need for ongoing research.
- The key recommendations include continuous temperature monitoring and prevention of fever for 72 hours, while avoiding active rewarming for mild hypothermia and prehospital cooling with cold fluids after restoring circulation.
Article Synopsis
- - These guidelines offer evidence-based recommendations for managing temperature in adults who remain comatose after cardiac arrest, updating previous 2021 guidelines from the European Resuscitation Council and the European Society of Intensive Care Medicine.
- - A panel of experts reviewed the evidence using the GRADE system and found that the level of certainty varied from moderate to low, leading to specific recommendations for monitoring temperature and preventing fever in patients.
- - Key recommendations include continuous core temperature monitoring, prevention of fever above 37.7 °C for at least 72 hours, and avoiding aggressive rewarming and prehospital cooling practices following return of spontaneous circulation.