Publications by authors named "C Gaudy-Graffin"
Introduction: Hepatitis E virus (HEV) can cause chronic infection (≥3 months) and cirrhosis in immunocompromised patients, especially kidney transplant recipients. Low alanine aminotransferase (ALT) levels and high HEV intrahost diversity have previously been associated with evolution toward chronicity in these patients. We hypothesized that additional clinical and viral factors could be associated with the risk of chronic HEV infection.
View Article and Find Full Text PDFBackground: Hepatitis E virus (HEV) is a zoonotic virus transmitted by pig meat and responsible for chronic hepatitis E in immunocompromised patients. It has proved challenging to reproduce this disease in its natural reservoir. We therefore aimed to develop a pig model of chronic hepatitis E to improve the characterization of this disease.
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- The study aimed to evaluate the connection between the concentration of anti-HBs antibodies and their ability to neutralize the hepatitis B virus, revealing that higher antibody levels do not always correspond to better neutralization effectiveness.
- It involved comparing IgG antibodies from individuals who received different types of hepatitis B vaccines or recovered from infection and testing their neutralization activity in vitro.
- The findings suggest that measuring anti-HBs levels alone is inadequate for assessing neutralization, recommending the inclusion of neutralization assays in quality control and highlighting the importance of matching vaccine types with circulating HBV strains.
A Home-Mailed Versus General Practitioner-Delivered Vaginal Self-Sampling Kit for Cervical Cancer Screening: A Cluster Randomized Controlled Trial with a Cost-Effectiveness Analysis.
J Womens Health (Larchmt)
October 2022
We assessed whether general practitioner (GP) delivery of a vaginal self-sampling kit was non-inferior to home-mailed delivery on cervical cancer screening (CCS) participation. Two hundred and ten French GPs from Indre-et-Loire French department were randomized into two groups, and their unscreened women patients aged 30-65 were included in February-March 2015. In the GP delivery group ( = 105 GPs; 1,806 women), women were sent a reminder letter inviting them to collect a vaginal self-sampling kit at their regular GP's practice.
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