Publications by authors named "C Garcia-Mouton"
Article Synopsis
- Mycobacterium tuberculosis forms biofilm-like cords that enhance its virulence, suppress the immune response, and promote cell death in lung tissues.
- These cords maintain structural integrity and resist antibiotic treatment due to their unique biophysical properties, allowing bacteria to remain active even in hostile environments.
- The research offers insights into how the mechanical properties of these bacterial aggregates influence tuberculosis infection and treatment effectiveness, highlighting the importance of understanding biofilm structures beyond individual bacterial behavior.
Pulmonary surfactant (PS) has been proposed as an efficient drug delivery vehicle for inhaled therapies. Its ability to adsorb and spread interfacially and transport different drugs associated with it has been studied mainly by different surface balance designs, typically interconnecting various compartments by interfacial paper bridges, mimicking in vitro the respiratory air-liquid interface. It has been demonstrated that only a monomolecular surface layer of PS/drug is able to cross this bridge.
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- The study examines how pulmonary surfactant (PS) interacts with antimicrobial peptides (AMPs) to explore their potential as a new treatment for bacterial infections in the airways.
- It specifically investigates whether PS can effectively transport AMPs like GRR10W4 without hindering their antimicrobial activity, showing that GRR10W4 can integrate into PS membranes.
- The findings suggest that combining PS with GRR10W4 enhances its antimicrobial effects while being less toxic to airway cells, highlighting a promising direction for improving inhaled therapies against infections.
This work is focused on the potential use of pulmonary surfactant to deliver full-length recombinant human surfactant protein SP-D (rhSP-D) using the respiratory air-liquid interface as a shuttle. Surfactant protein D (SP-D) is a collectin protein present in the pulmonary surfactant (PS) system, involved in innate immune defense and surfactant homeostasis. It has been recently suggested as a potential therapeutic to alleviate inflammatory responses and lung diseases in preterm infants suffering from respiratory distress syndrome (RDS) or bronchopulmonary dysplasia (BPD).
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