Publications by authors named "C Garcia-Monzon"
Given the lack of accurate diagnostic methods of acetaminophen (APAP)-induced acute liver failure (ALF), the search for new biomarkers for its diagnosis is an urgent need. The aim of this study was to evaluate the role of bone morphogenetic protein 6 (BMP6) in APAP-induced ALF progression and its potential value as a biomarker of ALF. Hepatic and circulating BMP6 expression was assessed in APAP-treated mice and in serum samples from patients with APAP overdose.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of protein kinase D2 (PKD2) in regulating insulin signaling and metabolic homeostasis in the liver, as its functions are not yet fully understood.
- Using various experimental methods, including PKD2 overexpression and specific gene depletion in mouse models, researchers assessed how PKD2 affects insulin responses and glucose metabolism.
- Findings reveal that PKD2 inhibits insulin signaling by modifying the phosphorylation of insulin receptor substrate 1 (IRS1), and suggest that PKD2 could be targeted therapeutically to combat hepatic insulin resistance.
Fibroblast growth factor 21 is a hepatokine involved in MASLD progression.
United European Gastroenterol J
October 2024
Article Synopsis
- The study aimed to evaluate the role of FGF21 in metabolic dysfunction-associated steatotic liver disease (MASLD) by analyzing both human samples and animal models.
- Significant increases in FGF21 gene expression and circulating levels were found in MASLD patients as well as in cell and animal models exposed to fatty acids.
- Additionally, the A-allele from the FGF21 rs838133 variant was linked to a higher risk of severe liver conditions in MASLD patients, indicating genetic factors may contribute to disease severity.
Article Synopsis
- This study looked at how a protein called COX-2 affects liver damage caused by a condition called cholestasis, where bile can't flow properly.
- Scientists used specially modified mice that always express COX-2 in their liver cells to see if it helps protect against liver injury.
- The results showed that these COX-2 mice had less liver damage and inflammation, improved bile acid processing, and were better at handling stress in the liver compared to regular mice.
Article Synopsis
- The study focused on patients with MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) and aimed to analyze the effects of different biochemical patterns (hepatocellular, mixed, and cholestatic) on liver damage, diagnostic accuracy, and prognosis.* -
- Results showed that the hepatocellular pattern had higher rates of liver inflammation, while the cholestatic pattern was more associated with cirrhosis; moreover, non-invasive tests were less accurate for detecting fibrosis in the hepatocellular pattern.* -
- The study highlighted that biochemical patterns largely remained consistent over time, with the cholestatic pattern linked to higher mortality risk, particularly in patients with age, diabetes, and cirrhosis.*