The exploration of new pharmacological compounds from endophytic fungi offers infinite possibilities. The aim of this study was to evaluate the antibacterial and antioxidant activities of extracts from the leaves of and five of its endophytic fungi and investigate the chemical diversity of the secondary metabolites produced. Isolated, purified, and molecularly identified endophytes and plant leaves were subjected to ethyl acetate extraction.
View Article and Find Full Text PDFBackground: species are the causative agent of Legionnaires' disease and, as ubiquitous waterborne bacteria, are prone to antimicrobial resistance gene (ARG) acquisition and dissemination due to the antimicrobial contamination of natural environments. Given the potential health risks associated with ARGs, it is crucial to assess their presence in the population.
Methods: The ARGs and were detected in 348 samples, isolates, and DNA extracts using conventional PCR.
Development of chiral organic materials with a strong chiroptical response is crucial to advance technologies based on circularly polarized luminescence, enantioselective sensing, or unique optical signatures in anti-counterfeiting. The progress in the field is hampered by the lack of structure-property relationships that would help designing new chiral molecules. Here, we address this challenge by synthesis and investigation of two chiral macrocycles that integrate in their structure a pseudo-meta [2.
View Article and Find Full Text PDFGut microbiota dysbiosis significantly contributes either to metabolic or immune diseases. Modulating the gut microbiome is the subject of intense research, but how immunonutritional ingredients from Chenopodium quinoa contribute to shaping the commensal microbiome and its metabolic capacities has not been determined. Sixty healthy volunteers participated in a double-blind, randomized parallel pilot study with two study arms: high fat-containing cookie and a C.
View Article and Find Full Text PDFBackground: Posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament injury and reconstruction (ACLR) is a prevalent cause of long-term disability. Few studies have compared the effect of ACLR timing on the development of PTOA.
Purpose/hypothesis: The purpose of this study was to compare the rate of PTOA at a long-term follow-up between patients who underwent early ACLR (<21 days after injury) versus delayed ACLR (>6 weeks after injury).