Spatial variability of nitrous oxide emissions from croplands and unmanaged natural ecosystems across a large environmental gradient.

Atmospheric nitrous oxide (NO) is a potent greenhouse gas, with long atmospheric residence time and a global warming potential 273 times higher than CO. NO emissions are mainly produced from soils and are influenced by biotic and abiotic factors that can be substantially altered by anthropogenic activities, such as land uses, especially when unmanaged natural ecosystems are replaced by croplands or other uses. In this study, we evaluated the spatial variability of NO emissions from croplands (maize, soybean, wheat, and sugar cane crops), paired with the natural grasslands or forests that they replaced across a wide environmental gradient in Argentina, and identified the key drivers governing the spatial variability of NO emissions using structural equation modeling.

RET signalling in the pituitary: a double-edged sword for differentiation, apoptosis and therapeutic strategies in acromegaly.

The discovery of RET mutations in Multiple Endocrine Neoplasia 2A (MEN2A) in 1993 ignited a revolution in our understanding of this versatile receptor. Since then, RET's influence has expanded to encompass diverse organs, including the pituitary gland. This review explores the multifaceted role of RET in somatotrophs, focusing on two opposing pathways: proliferation versus differentiation and apoptosis.

Impedimetric Sensor for SARS-CoV-2 Spike Protein Detection: Performance Assessment with an ACE2 Peptide-Mimic/Graphite Interface.

The COVID-19 pandemic has prompted the need for the development of new biosensors for SARS-CoV-2 detection. Particularly, systems with qualities such as sensitivity, fast detection, appropriate to large-scale analysis, and applicable in situ, avoiding using specific materials or personnel to undergo the test, are highly desirable. In this regard, developing an electrochemical biosensor based on peptides derived from the angiotensin-converting enzyme receptor 2 (ACE2) is a possible answer.

Pancreaticoduodenectomy in trauma patients with grade IV-V duodenal or pancreatic injuries: a post hoc analysis of an EAST multicenter trial.

Introduction: The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management of grade IV-V pancreaticoduodenal injuries.

Methods: This is a retrospective, multicenter analysis from 35 level 1 trauma centers from January 2010 to December 2020.