Publications by authors named "C Garbar"

Luminal breast cancers represent 70% of newly diagnosed breast cancers per annum and have a relatively good prognosis compared with triple-negative breast cancers. Luminal tumors that are responsive to hormonal therapy are particularly associated with a favorable prognosis. Nonetheless, the absolute number of metastatic relapses in luminal cancers is larger than in triple-negative breast cancers.

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Background: The COVID-19 pandemic led to a widely documented disruption in cancer care pathway. Since a resurgence of the pandemic was expected after the first lockdown in France, the global impact on the cancer care pathway over the year 2020 was investigated.

Aims: This study aimed to describe the changes in the oncology care pathway for cancer screening, diagnosis, assessment, diagnosis annoucement procedure and treatment over a one-year period.

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Melanoma is responsible for 90% of skin cancer-related deaths. Major therapeutic advances have led to a considerable improvement in the prognosis of patients, with the development of targeted therapies (BRAF or MEK inhibitors) and immunotherapy (anti-CTLA-4 or -PD-1 antibodies). However, the tumor constitutes an immunosuppressive microenvironment that prevents the therapeutic efficacy and/or promotes the development of secondary resistances.

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Article Synopsis
  • * The study focused on the effects of apelin deficiency on the aorta's vascular stiffness and structural changes in mice, exploring how this factor, linked to obesity, influences inflammation and remodeling in white adipose tissue.
  • * Results showed that apelin-deficient mice experienced significant inflammation and alterations in their aortic walls, suggesting that the secretions from their adipose tissue could contribute to vascular stiffening through mechanisms like collagen buildup and breakdown of elastic fibers.
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