Publications by authors named "C Gani"
Background: Preoperative chemoradiotherapy combined with total mesorectal excision (TME) is a standard treatment for locally advanced rectal cancer (LARC). However, lateral pelvic lymph nodes (LPLNs) are often inadequately treated with standard regimens. This study examines the treatment and postoperative outcomes in LARC patients receiving a simultaneous integrated boost (SIB) for LPLNs during long-course chemoradiotherapy.
View Article and Find Full Text PDFBackground And Purpose: Neoadjuvant chemoradiotherapy (NCRT) is a standard treatment option for locally advanced rectal cancer. However, there is still conflicting data about the genetic landscape and potential dynamics during and after NCRT. This study evaluated oncogenic driver mutations before NCRT and investigated corresponding resection samples after treatment.
View Article and Find Full Text PDFSimulation-free magnetic resonance-guided radiation therapy of prostate cancer.
Phys Imaging Radiat Oncol
October 2024
Background And Purpose: Despite recent advances of online image-guided high-precision patient positioning and adaptation using magnetic resonance imaging (MRI) or cone-beam computed tomography (CT), standard radiation therapy pathway still involves a dedicated simulation scan. The aim of this study was to evaluate the feasibility and planning quality of integrating a simulation-free treatment planning workflow for adaptive online MRI-guided radiation therapy on a 1.5 T MRI linear accelerator (MRI-Linac) in prostate cancer using diagnostic CT (dCT) scans.
View Article and Find Full Text PDFArticle Synopsis
- Conventional image-guided radiotherapy (conv-IGRT) for prostate cancer fails to account for anatomical changes between treatment sessions, while online-adaptive magnetic resonance guided radiotherapy (OA-MRgRT) has potential for better sparing of critical organs and improved targeting.
- The study analyzed dose accumulation in ten prostate cancer patients treated with OA-MRgRT versus conv-IGRT, using advanced imaging techniques for dose mapping.
- Results showed that while both methods yielded similar target dose parameters, OA-MRgRT delivered lower doses to organs-at-risk like the rectum and bladder compared to conv-IGRT, though these differences didn't lead to clinically significant outcomes.
Background: In locally advanced rectal cancer, the prediction of tumor response during and after neoadjuvant treatment remains challenging. In terms of organ preservation, adaptive radiotherapy, and intensified (total) neoadjuvant therapies, biomarkers are desirable for patient stratification.
Methods: In 16 patients, weekly blood samples (n = 86) to detect cell-free tumor DNA (ctDNA) during long-course neoadjuvant chemoradiotherapy were analyzed.