Publications by authors named "C Galambrun"
Lymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivo development and function of helper-like innate lymphoid cells (ILCs) in humans remain much less well understood than those of T, B, and NK cells. We monitored hematopoietic stem cell transplantation (HSCT) to determine the kinetics of ILC development in both children and adults.
View Article and Find Full Text PDFBackground: to evaluate the safety and efficacy of a physical activity program (PAP) in children and adolescents with cancer.
Methods: children and adolescents with cancer were randomly assigned in a 1:1 ratio to the six-month PAP (intervention group) or to the control group. The first evaluation was performed at the end of the PAP (T0 + 6 mo).
Background: Lung involvement in childhood Langerhans cell histiocytosis (LCH) is infrequent and rarely life threatening, but occasionally, severe presentations are observed.
Methods: Among 1482 children (< 15 years) registered in the French LCH registry (1994-2018), 111 (7.4%) had lung involvement.
Article Synopsis
- The study examined medication non-adherence (NA) in French adult and pediatric recipients after allogeneic hematopoietic cell transplantation (allo-HCT), finding about 75% of both groups reported NA.
- Key factors linked to NA in adults included being under 50 years old, using specific medications (cyclosporine, valacyclovir/acyclovir), and experiencing side effects, with age being the most significant factor.
- The research is the first of its kind in France and indicates a need for further studies, particularly to better understand NA in pediatric patients who are most vulnerable.
Article Synopsis
- Busulfan is a key drug used before hematopoietic stem cell transplantation, but achieving consistent dosing is challenging, especially in neonates and infants.
- An observational study initiated in 2005 analyzed data from 540 patients to create a population pharmacokinetic model that considers body weight and maturation, which significantly reduced variability in drug clearance.
- The new dosing model showed improved drug exposure for children under 16 kg compared to previous methods and suggests that therapeutic drug monitoring is essential for young patients and those with specific conditions.