Publications by authors named "C Gabelli"
Article Synopsis
- Internet-based psychological interventions offer accessible mental health care, addressing barriers like distance, cost, and safety, but research on their effects on biomarkers is limited.
- This systematic review examines how these interventions impact biomarkers across various clinical and nonclinical populations, with a secondary focus on whether changes in biomarkers relate to improvements in psychological or physical symptoms.
- Out of 24 studies analyzed, a diverse range of participants included those with psychiatric issues, medical diseases, and nonclinical individuals, indicating some effectiveness of cognitive behavioral therapy (CBT) in reducing certain biomarkers.
Background: Advances in analytical methods have recently paved the way to Alzheimer's disease (AD) biomarkers testing in blood along with the more established CSF testing. To ensure a forthcoming application of this low-invasive diagnostic that might allow to recognize early onset of dementia, appropriate pathological cut-points need to be defined.
Methods: In this cross-sectional study we measured blood and CSF neurofilament light chain (NFL), phosphorylated tau (pTau 181), Amyloid-β1-42 (AB 1-42) and Amyloid-β1-40 (AB 1-40) on a fully automated chemiluminescent platform (Lumipulse, Fujirebio) in 80 cognitively impaired patients and 55 cognitively unimpaired subjects.
Article Synopsis
- Value-based laboratory medicine focuses on improving patient outcomes by enhancing the clinical utility of diagnostic tests while optimizing resources and reducing costs.
- Key elements include the organization of diagnostics, translating lab data into meaningful clinical information, and addressing ethical considerations such as patient empowerment and big data analysis.
- The paper summarizes insights from the EFLM Strategic Conference and highlights the importance of education, technological advancements, and future regulations in shaping the profession.
The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological aging [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning with a broader trend of integrating non-pharmacological approaches into dementia care.
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