Finite element modeling of an intact and cracked mandibular second molar under quantitative percussion diagnostics loading.

Statement Of Problem: Quantitative percussion diagnostics (QPD) has been devised to nondestructively evaluate the mechanical integrity of human teeth and implants, the mechanical integrity of the underlying bone, and the presence of cracks, but the mechanism is not clearly understood.

Purpose: The purpose of this study is to better understand the dynamic behavior of a tooth under conditions consistent with QPD by focusing on physiologically accurate 3D finite element models of a human mandibular second molar with surrounding tissues.

Material And Methods: Finite element analysis (FEA) was used to study the force response of dental structures measured by the sensor in a QPD handpiece.

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin.

In this study, we report a novel platinum-doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment. This new molecular structure () was formed by conjugating an amphiphilic Pt(IV) prodrug of cisplatin with doxorubicin. Due to its amphiphilic nature, the Pt(IV)-doxorubicin conjugate effectively penetrates cell membranes, delivering both cisplatin and doxorubicin payloads intracellularly.

Association Between Social Vulnerability and Streptococcus pneumoniae Antimicrobial Resistance in US Adults.

Background: Growing evidence indicates antimicrobial resistance disproportionately affects individuals living in socially vulnerable areas. This study evaluated the association between the CDC/ATSDR Social Vulnerability Index (SVI) and Streptococcus pneumoniae (SP) antimicrobial resistance (AMR) in the United States.

Methods: Adult patients ≥18 years with 30-day nonduplicate SP isolates from ambulatory/hospital settings from January 2011 to December 2022 with zip codes of residence were evaluated across 177 facilities in the BD Insights Research Database.

An evaluation of quantitative percussion diagnostics for determining the probability of a microgap defect in restored and unrestored teeth: A prospective clinical study.

Statement Of Problem: Current dental diagnostics are image based and cannot detect a structural microgap defect such as a crack in a tooth. Whether percussion diagnostics can effectively diagnose a microgap defect is unclear.

Purpose: The purpose of the present study was to determine from a large multicenter prospective clinical study whether quantitative percussion diagnostics (QPD) could detect structural damage in teeth and whether a probability of its presence could be provided.

Thermal Performance Curves of Multiple Isolates of , a Lethal Pathogen of Amphibians.

Emerging infectious disease is a key factor in the loss of amphibian diversity. In particular, the disease chytridiomycosis has caused severe declines around the world. The lethal fungal pathogen that causes chytridiomycosis, (), has affected amphibians in many different environments.