Publications by authors named "C G ROSEN"
Introduction: There is increasing prevalence of single-use flexible laryngoscopes in Otolaryngology. This study aims to quantify and compare the environmental outcomes of single-use disposable flexible laryngoscopes (SUD-Ls) and reusable flexible laryngoscope (R-Ls).
Methods: The ISO 14040 standardized Life Cycle Assessment (LCAs) was utilized to estimate the environmental footprint of SUD-L and R-L.
Regeneration of orofacial bone defects caused by inflammatory-related diseases or trauma remains an unmet challenge. Parathyroid hormone 1 receptor (PTH1R) signaling is a key mediator of bone remodeling whereas the regulatory mechanisms of PTH1R signaling in oral bone under homeostatic or inflammatory conditions have not been demonstrated by direct genetic evidence. Here we observed that deletion of PTH1R in Gli1+-progenitors led to increased osteogenesis and osteoclastogenesis.
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- - Bone health is maintained by the balance between bone formation and resorption, with osteoblasts playing a crucial role in forming new bone, a process requiring ATP and potentially impacted by systemic metabolic changes, especially in conditions like type 2 diabetes mellitus (T2DM).
- - Research shows that obese mice on a high-fat diet exhibit reduced bone quality and formation rates, correlating with increased lipid droplet accumulation in osteoblasts, which suggests that impaired lipid metabolism affects bone health.
- - A new experiment with a murine model demonstrated that deleting a specific lipid storage protein (Plin2) in osteoblasts can improve lipid breakdown and enhance bone formation, indicating that boosting fatty acid oxidation may counteract bone dysfunction caused by
Introduction Artificial intelligence (AI) has long garnered significant interest in the medical field. Large language models (LLMs) have popularized the use of AI for the public through chatbots such as ChatGPT and have become an easily accessible and recognizable medical resource for medical students. Here, we investigate how medical students are currently utilizing LLM-based tools throughout medical education and examine medical student perception of these tools.
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- High levels of follicle-stimulating hormone (FSH) in post-menopausal women are linked to the development of Alzheimer's disease (AD), as shown by studies in mice.
- Mice lacking FSH receptors displayed improved spatial memory, indicating that blocking FSH signaling can help prevent memory loss related to aging and AD-like pathology.
- The findings suggest that targeting FSH could be a potential strategy for preventing memory deficits in post-menopausal women.