Publications by authors named "C G Kevil"
The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl- channel. We examined if CLCA1/TMEM16A had a role in DKD.
View Article and Find Full Text PDFViViEchoformer: Deep Video Regressor Predicting Ejection Fraction.
J Imaging Inform Med
November 2024
Heart disease is the leading cause of death worldwide, and cardiac function as measured by ejection fraction (EF) is an important determinant of outcomes, making accurate measurement a critical parameter in PT evaluation. Echocardiograms are commonly used for measuring EF, but human interpretation has limitations in terms of intra- and inter-observer (or reader) variance. Deep learning (DL) has driven a resurgence in machine learning, leading to advancements in medical applications.
View Article and Find Full Text PDFArticle Synopsis
- Pulmonary arterial hypertension (PAH) is a severe lung condition increasingly linked to methamphetamine use, and this study investigates trends and demographics of PAH patients with and without the drug.
- Data from national healthcare databases covering 2008-2020 revealed a notable 9.2-fold rise in hospitalization rates for PAH patients who also used methamphetamine, with a majority being middle-aged male, White, low-income individuals primarily from Western and Southern US regions.
- The findings indicate a significant correlation between methamphetamine use and increased PAH hospitalizations, with the prevalence among users being 32 times higher than non-users, particularly among males and those aged 41-64.
The incidence of metabolic dysfunction-associated steatohepatitis (MASH) is on the rise, and with limited pharmacological therapy available, identification of new metabolic targets is urgently needed. Oxalate is a terminal metabolite produced from glyoxylate by hepatic lactate dehydrogenase (LDHA). The liver-specific alanine-glyoxylate aminotransferase (AGXT) detoxifies glyoxylate, preventing oxalate accumulation.
View Article and Find Full Text PDFBackground: Methamphetamine is an emerging drug threat. The disparity in cardiomyopathy-associated hospital admissions among methamphetamine users (CAHMA) over the decade remains unknown.
Objectives: The purpose of this study was to determine the trends and prevalence of CAHMA by age, sex, race, and geographical region.