Publications by authors named "C G Jennings"
The aggregation of α-synuclein is crucial to the development of Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. The aggregation pathway of α-synuclein typically involves a defined sequence of nucleation, elongation, and secondary nucleation, exhibiting prion-like spreading. This study employed Raman spectroscopy and machine learning analysis, alongside complementary techniques, to characterize the biomolecular changes during the fibrillation of purified recombinant wild-type α-synuclein protein.
View Article and Find Full Text PDFIntroduction: Nurse researchers often lack awareness of how to start a clinical academic research career and often lack clear entry routes. This scoping review aims to identify the range and nature of clinical academic opportunities available for nurses. This will also identify the knowledge gaps and provide the basis for future research.
View Article and Find Full Text PDFObjective: To provide a video tutorial on the diagnostic ultrasound approach to the medial compartment of the canine shoulder and provide comparisons of normal and pathological images with corresponding MRI.
Animals: Dogs undergoing diagnostic ultrasound of the medial shoulder.
Methods: The medial shoulder was positioned in flexion with external rotation to allow transducer access, clipped, and scrubbed with dilute chlorhexidine.
Article Synopsis
- - The study highlights the importance of user input in creating digital health interventions (DHIs) to improve their acceptance for secondary prevention of cardiovascular disease (CVD).
- - A co-design approach was employed in developing the INTERCEPT DHI, involving health professionals and users in a four-phase process to ensure the app meets real needs and is user-friendly.
- - Key design principles such as simplicity, personalization, and social support were identified, leading to significant improvements in usability scores after testing and implementing user feedback.
Background: Implementation of the cardiovascular disease (CVD) prevention guidelines in the UK has been repeatedly evaluated under the auspices of the British Cardiovascular Society in three Action on Secondary and Primary Prevention by Intervention to Reduce Events (ASPIRE) surveys in 1994-1995, 2008-2010 and 2017-2019. The primary care arm of ASPIRE-2-PREVENT (A-3-P) was conducted to evaluate lifestyle and medical risk factor management in people at high risk of atherosclerotic CVD in everyday clinical practice.
Methods: A-3-P was a cross-sectional survey in 27 general practices and health centres across 5 English National Health Service regions.