Publications by authors named "C G De los Reyes-Gavilan"
Colorectal cancer (CRC) development is a gradual process in which progressive histological alterations of the intestinal mucosa damage occur over years. This process can be influenced by modifiable external factors such as lifestyle and diet. Most CRC cases (>80%) originate from conventional adenomas through the adenomatous pathway and usually harbour dysplastic cells, whereas the serrated pathway is less frequent (<20% cases) and comprises hyperplastic polyps and other polyps containing dysplastic cells.
View Article and Find Full Text PDFArticle Synopsis
- Research on the microbiota-gut-brain axis in autism has largely focused on bacteria, with fungi being underexplored, prompting a study on fungal involvement in Tunisian children with autism spectrum disorder.
- The study involved fecal sample analysis from 28 autistic children and 46 controls; they identified fungal isolates and tested their antifungal susceptibility and virulence factors.
- Results showed a significant presence of fungi in both groups, with specific antifungal resistance and virulence traits in the isolates, indicating a potential link between gut fungi and autism that warrants further investigation.
Article Synopsis
- A study investigated how fiber and probiotic supplements can help protect against colon damage and gut microbiota changes caused by harmful substances (PhIP and DSS) in male Fischer-344 rats.* -
- The results showed that while PhIP and DSS caused significant inflammation and damage to the colon, fiber reduced this damage and inflammation, and probiotics increased colon length.* -
- Additionally, fiber shifted the gut microbiota toward less inflammation, contrasting with the negative changes seen after exposure to PhIP and DSS without supplements.*
Diet is one of the main exogenous sources of potentially carcinogenic nitrosamines (NAs) along with tobacco and cosmetics. Several factors can affect endogenous N-nitroso compounds (NOCs) formation and therefore the potential damage of the intestinal mucosa at initial colorectal cancer stages. To address this issue, 49 volunteers were recruited and classified according to histopathological analyses.
View Article and Find Full Text PDFArticle Synopsis
- Investigated relationships among intestinal mucosal lesions, fecal enzymatic activities, and gut microbiota profiles in individuals participating in a colorectal cancer screening.
- Samples were collected from 54 volunteers, comparing fecal and intestinal mucosa data between control groups and those with various types of polyps.
- Notable findings include increased α-glucosidase activity in individuals with conventional adenomas and specific shifts in microbial abundance linked to enzyme levels, suggesting potential implications for colorectal cancer risk assessment.