Publications by authors named "C G C Ooi"
Purpose: Denileukin diftitox (DD)-cxdl is a fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2. This phase III, multicenter, open-label, single-arm registrational trial evaluated the efficacy and safety of DD-cxdl in patients with relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL).
Patients And Methods: In the main study, which followed a dose-finding lead-in, DD-cxdl was administered intravenously daily (5 days; 9 µg/kg/d once daily) every 21 days for up to eight cycles.
Antarctica and the Southern Ocean are key elements in the physical and biological Earth system. Human-induced climate change, and other human activities in the region, are leading to several potential interacting tipping points with major and irreversible consequences. Here, we examine eight potential physical, biological, chemical, and social Antarctic tipping points.
View Article and Find Full Text PDFBackground And Aim: The COVID-19 pandemic necessitated the transition to online medical education. This study evaluated the efficacy of online case-based tutorials using a serious game tutorial [PlayMed™ (PM)], as compared to a traditional slideshow tutorial (TT).
Methods: We performed a prospective, mixed-methods, randomised controlled trial on undergraduate medical students during the COVID-19 pandemic, from May 2020 to January 2021.
Article Synopsis
- Advanced ultrasound techniques offer better insights into non-melanoma skin cancers compared to traditional methods like dermoscopy, enhancing assessment of tumor margins and morphology.
- In a study of 11 skin tumors (mostly basal and squamous cell carcinomas) from patients aged 66 to 98, ultrasound effectively measured tumor depth and correlated well with histological findings.
- The ultrasound showed that all tumors were solid and stiff, with high levels of neovascularity, indicating its potential as a quick and useful pre-operative tool.
Article Synopsis
- * Key challenges include the immiscibility of triacylglycerols with water and the lower efficiency of enzymes relative to chemical catalysts.
- * The review suggests that using chemical additives, particularly a combination of ionic liquids and polyols, can significantly enhance enzymatic hydrolysis efficiency, making the process more effective and less damaging to enzymes.