Intravitreal bevacizumab at 4-month intervals for prevention of macular edema after plaque radiotherapy of uveal melanoma.

Purpose: To evaluate the efficacy of intravitreal bevacizumab for prevention of macular edema after plaque radiotherapy of uveal melanoma.

Design: Retrospective, single-center, nonrandomized, interventional comparative study.

Participants: Patients with uveal melanoma treated with plaque radiotherapy were divided into 2 groups: a bevacizumab group and a control group.

Ciliary body and choroidal pseudomelanoma from ultrasonographic imaging of hypermature cataract in 20 cases.

Purpose: To describe a series of 20 patients with opaque media, referred with uveal melanoma, but subsequently found to have pseudomelanoma from oblique imaging of hypermature cataract on ultrasonography.

Design: Case series.

Participants: Twenty patients.

Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome.

Purpose: Uveal melanoma (UM) was a fatal malignancy in 40% to 50% of cases. The aim of this study is to evaluate the independent contributions of chromosome 1, 3, 6, and 8 abnormalities for prognostication of metastasis, and to define multichromosome copy number aberration (CNA) signatures that can be used to evaluate risk.

Methods: A series of 320 UM were analyzed for chromosome 1, 3, 6, and 8 abnormalities using whole genome single-nucleotide polymorphism arrays.

Single-agent, minimal dose, minimal exposure intraarterial chemotherapy for retinoblastoma in a 4-month-old infant.

Purpose: To document minimal dose and minimal exposure of chemotherapy for unilateral retinoblastoma.

Methods: A 4-month-old infant developed leukocoria in the right eye and was found to have unilateral sporadic retinoblastoma.

Results: The right eye was classified as Group D retinoblastoma, with a single large tumor, moderate subretinal seeding, and total retinal detachment.