Listening to children with lower limb loss: Rationale, design, and protocol for delivery of a novel globally applicable research toolkit-Prosthetic user needs, quality of life, pain, and physical function.

Introduction: Rehabilitation after childhood lower limb loss is complex and dependent on multiple stakeholders and environmental factors. While research with adults underscores the importance of involving prosthetic limb users and caregivers in discussions to drive innovation, children are often excluded or not effectively engaged. This protocol lays out the development and implementation protocol for an internationally applicable research toolkit which has been designed and evaluated around the essential presence of the child.

Supporting patients and clinicians during the breast cancer care path with AI: The Arianna solution.

The onset of cancer disease is a traumatic experience for both patients and their families that suddenly change the patient's life and is accompanied by important physical, emotional, and psycho-social problems. The complexity of this scenario has been exacerbated by the COVID-19 pandemic which dramatically affected the continuity of the provision of optimal care to chronic patients. Telemedicine can support the management of oncology care paths by furnishing a suite of effective and efficient tools to monitor the therapies of cancer patients.

How do I update my model? On the resilience of Predictive Process Monitoring models to change.

Existing well-investigated Predictive Process Monitoring techniques typically construct a predictive model based on past process executions and then use this model to predict the future of new ongoing cases, without the possibility of updating it with new cases when they complete their execution. This can make Predictive Process Monitoring too rigid to deal with the variability of processes working in real environments that continuously evolve and/or exhibit new variant behaviours over time. As a solution to this problem, we evaluate the use of three different strategies that allow the periodic rediscovery or incremental construction of the predictive model so as to exploit new available data.

Bone Marrow Stroma and Vascular Contributions to Myeloma Bone Homing.

Purpose Of The Review: Herein we dissect mechanisms behind the dissemination of cancer cells from primary tumor site to the bone marrow, which are necessary for metastasis development, with a specific focus on multiple myeloma.

Recent Findings: The ability of tumor cells to invade vessels and reach the systemic circulation is a fundamental process for metastasis development; however, the interaction between clonal cells and the surrounding microenvironment is equally important for supporting colonization, survival, and growth in the secondary sites of dissemination. The intrinsic propensity of tumor cells to recognize a favorable milieu where to establish secondary growth is the basis of the "seed and soil" theory.