Publications by authors named "C Frey"
Background: Injury to the posterior vasculature is a potential complication in orthopaedic knee surgery that may be associated with variations in its anatomy, such as the type II-A2 variant, which places the anterior tibial artery (ATA) in closer proximity to the tibia. However, how close surgical instrumentation comes to injuring the ATA is not well described.
Purpose: To determine how the type II-A2 variant of the popliteal vasculature affects proximity of the ATA to instrumentation for orthopaedic knee procedures.
Article Synopsis
- Cutaneous lupus erythematosus (CLE) is a skin-related manifestation of lupus erythematosus, classified into subtypes (acute, subacute, chronic) based on clinical characteristics and lab findings.
- Traditional treatments include topical corticosteroids and antimalarial drugs, but new immunomodulatory therapies, particularly Janus kinase (JAK) inhibitors, are emerging options.
- The review highlights the importance of understanding the JAK/STAT signaling pathway in CLE management and calls for more research on the safety and effectiveness of JAK inhibitors for autoimmune disease treatment.
Article Synopsis
- The study focuses on assessing the impact of buprenorphine-naloxone on mortality and remission rates among patients with opioid use disorder (OUD), amidst rising opioid-related deaths in the U.S.
- Using data from nearly 92 million medical records, the research compares outcomes between patients treated with buprenorphine-naloxone and a control group not receiving this treatment.
- Findings indicate that patients on buprenorphine-naloxone experienced 34% fewer deaths and approximately 1.9 times higher remission rates compared to those who did not receive the medication.
A new approach to sample preparation and enzymatic digestion in bottom-up proteomics has been developed using alginate-based hydrogel entrapment of enzymes. This hydrogel facilitates rapid and room-temperature digestions with multienzyme capabilities. Three methodologies were tested: within microcentrifuge tubes, pipette tips, and automated robotic liquid handling.
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