Regulatory elements in (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits.

Purpose: The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a congenital condition defined by premature fusion of 1 or both coronal sutures, remains largely unknown.

Methods: We conducted the largest genome-wide association study of cNCS followed by replication, fine mapping, and functional validation of the most significant region using zebrafish animal model.

Results: Genome-wide association study identified 6 independent genome-wide-significant risk alleles, 4 on chromosome 7q21.

Pandemic bordering: domestic politicisation, European coordination, and national border closures in the COVID-19 crisis.

When the member states imposed unilateral restrictions on the cross-border movement of persons and goods in their initial response to the COVID-19 pandemic, the EU appeared to relapse into the 'politics trap' of earlier integration crises. However, our analysis of entry restrictions for persons in France, Germany, Italy, the Netherlands, and Poland from the end of 2019 to the summer of 2022 shows no systematic relationship between domestic politicisation and national border closures. Rather, border closures followed the course of the pandemic as well as EU recommendations.

Variation of resection margins in oral cancer in dependence of tumor stage and subsite - a retrospective cohort study.

Objectives: Surgical resection is a key component of the treatment of head and neck cancer and the achievement of free surgical margins are essential for the patients' outcome in terms of survival. While there is a general recommendation for a free resection range of 5 mm, up to date, there is a lack of investigations on the quality of tumor resection in dependence of affected subsite and tumor stage. In the presented study, predictors for the achieved resection margins in surgically treated oral squamous cell carcinomas were analyzed.