Navigating Pediatric Pain: Emerging Trends and Best Practice.

This article examines the pivotal role of critical care nurses in managing pediatric pain, emphasizing the multifaceted nature of care. It covers the challenges and opportunities nurses face, stressing the importance of education and training. The background section underscores the global issue of inadequately managed pediatric pain and the importance of addressing social determinants of health while recognizing perceptions, beliefs, stereotypes, and biases on pain management.

Microaggressions in Nursing.

How to address these behaviors to promote health equity and inclusion.

The hyphal-specific toxin candidalysin promotes fungal gut commensalism.

The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and as multicellular hyphae to adapt to its environment. The current dogma of C.

Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans.

The ability of the fungus Candida albicans to filament and form biofilms contributes to its burden as a leading cause of hospital-acquired infections. Biofilm development involves an interconnected transcriptional regulatory network (TRN) consisting of nine transcription factors (TFs) that bind both to their own regulatory regions and to those of the other network TFs. Here, we show that seven of the nine TFs in the C.

Phase separation in fungi.

Phase separation, in which macromolecules partition into a concentrated phase that is immiscible with a dilute phase, is involved with fundamental cellular processes across the tree of life. We review the principles of phase separation and highlight how it impacts diverse processes in the fungal kingdom. These include the regulation of autophagy, cell signalling pathways, transcriptional circuits and the establishment of asymmetry in fungal cells.