Publications by authors named "C Franchisseur"
Article Synopsis
- A study compared the analgesic effects of "superficial" and "deep" repetitive transcranial magnetic stimulation (rTMS) in patients with central neuropathic pain, with 59 patients randomly assigned to receive active or sham stimulation using different coils.
- Results showed significant pain relief from both treatments compared to a sham, with immediate effects from the superficial stimulation and delayed but longer-lasting effects from the deep stimulation.
- Both stimulation types provided similar levels of pain relief, suggesting different mechanisms may be at play, and involved various secondary outcomes like pain interference and depression.
The thermal grill illusion of pain (TGIP) is a paradoxical burning pain sensation elicited by the simultaneous application of innocuous cutaneous warm and cold stimuli with a thermode ("thermal grill") consisting of interlaced heated and cooled bars. Its neurophysiological mechanisms are unclear, but TGIP may have some mechanisms in common with pathological pain, including central sensitization in particular, through the involvement of N-methyl- d -aspartate receptors. However, few studies have investigated TGIP in patients with chronic pain and its clinical relevance is uncertain.
View Article and Find Full Text PDFEffects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal adenomas.
Nutr Cancer
August 2006
Intervention studies of colorectal adenoma recurrence have demonstrated the need for surrogate markers of the cancer risk. Short-chain fructo-oligosaccharides (sc-FOS) have protective actions on colon carcinogenesis in animal models. We investigated differences in biological markers between adenoma and adenoma-free subjects, before and after 3 mo of daily intake of 10 g sc-FOS, within a multicenter study.
View Article and Find Full Text PDFIn order to identify biomarkers of colorectal tumors, 20 subjects with colorectal adenomas were compared with 20 controls as regards fecal parameters (pH, short-chain fatty acids, bile acids, and sterols), blood parameters (bile acids, cholesterol, triglycerides, glycemia and insulinemia), and rectal cell proliferation. Variables were compared by unconditional logistic regression, controlling for gender. There were significant and positive associations between risk of adenoma and total fecal primary bile acids and serum cholesterol, with odds ratios for the third versus first tertile = 9.
View Article and Find Full Text PDFBackground: An elevated plasma total homocysteine (tHcy) concentration seems to increase the risk of cardiovascular disease.
Objective: We evaluated the determinants of tHcy in healthy French adults.
Design: tHcy was measured by HPLC and fluorometric detection in 1139 women and 931 men aged 35-60 y.