Publications by authors named "C Fouassier"
Background: Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease of the central nervous system caused by JC virus (JCV). Survival is dependent on early diagnosis and ability to re-establish anti-viral T cell immunity. Adoptive transfer of polyomavirus-specific T cells has shown promise; however, there are no readily available HLA-matched anti-viral T cells to facilitate rapid treatment.
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- Vitamin B12 is essential for blood cell formation and nerve insulation, and its deficiency can lead to neurological issues despite normal blood levels, as seen in a patient with symptoms like tremor and cognitive decline.
- Researchers discovered an autoantibody against the transcobalamin receptor (CD320) that hinders vitamin B12 uptake in the brain, resulting in low levels found in cerebrospinal fluid even when blood levels appear normal.
- The study suggests this autoimmune condition can be treated with immunosuppressive therapy and high-dose vitamin B12, and highlights the importance of recognizing how B12 transport differs in various tissues, which could improve diagnosis and treatment strategies for similar neurological disorders.
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- Scientists studied a group of people with multiple sclerosis (MS) to find a special antibody that could help diagnose the disease.
- They found that about 10% of these patients had a unique pattern of antibodies that could appear years before they showed any symptoms of MS.
- This discovery might help doctors identify people at high risk for MS earlier, even before the disease fully develops.
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster of PwMS that share an autoantibody signature against a common motif that has similarity with many human pathogens.
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- - A patient in California survived a rare and often fatal infection called Balamuthia mandrillaris granulomatous amebic encephalitis after receiving a new treatment approach.
- - The treatment included nitroxoline, a drug originally developed for urinary tract infections, which was found to have effectiveness against the ameba.
- - Researchers identified nitroxoline through a screening process aimed at finding drugs that can kill Balamuthia, showcasing the potential for repurposing existing medications.