A degenerate HLA-DR epitope pool of HER-2/neu reveals a novel in vivo immunodominant epitope, HER-2/neu88-102.

Purpose: Over the past two decades, there has been significant interest in targeting HER-2/neu in immune-based approaches for the treatment of HER-2/neu+ cancers. For example, peptide vaccination using a CD8 T cell-activating HER-2/neu epitope (amino acids 369-377) is an approach that is being considered in advanced phase clinical trials. Studies have suggested that the persistence of HER-2/neu-specific CD8 T cells could be improved by incorporating human leukocyte antigen (HLA) class II epitopes in the vaccine.

[Possibility of prenatal ultrasonic diagnosis of growth defects in fetal long bones. Report of a case].

Recent advances in echographic diagnosis and its application during the first three months of pregnancy provide a direct method for assessment in both normal and pathological pregnancies. Given their frequency, the study was focused on the congenital structural anomalies of fetal limbs. The possibility of the repetition of these malformations in the same patient is very high, ranging from 2-25%.

Integrated techniques in the identification of ovarian tumors.

This work is intended to be an effort to standardise the diagnostic iter of ovarian pathology. This protocol is carried out with a clinical examination and later by USG and celioscopy. It tests the management of functional and endometriosic cysts and the other ovarian pathologies.

Echopatterns of the ovarian dermoid tumor.

The authors report the ovarian dermoid echopatterns observed in 189 cases. The ultrasonic key of the diagnosis is a particular "pearly-gray" colour. The early diagnosis by USG gives the Gynecologist some advantages in: a) avoiding the operation in those cases of small mass; b) making a pfammenstiel incision in the surgical operation; c) trying a conservative surgery.