Publications by authors named "C Flower"
Article Synopsis
- Coordination of cellular signaling and adaptive metabolism is crucial for energy balance and homeostasis, with phosphorylation being a key regulatory mechanism for metabolic networks.
- The study categorizes phosphorylation sites on metabolic enzymes, finding that many are located near functional areas and emphasizing ones on oxidoreductases, particularly phosphotyrosine sites linked to enzyme function.
- Using a high fat diet model, the research uncovers sex-specific changes in metabolic regulation and identifies specific phosphotyrosine sites that predict metabolic responses, revealing how they influence enzyme activity and metabolic pathways.
Systemic lupus erythematosus (SLE) is a complex autoimmune condition that disproportionately impacts non-White ethnic and racial groups, particularly individuals in the African diaspora who experience heightened incidence, prevalence, and adverse outcomes. Genetic and epigenetic factors play significant roles in SLE risk, however these factors neither explain the whole of SLE risk nor the stark racial disparities we observe. Moreover, our understanding of genetic risk factors within African ancestry populations is limited due to social and environmental influences on research participation, disease presentation, and healthcare access.
View Article and Find Full Text PDFA major contributor to poor sensitivity to anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation, whereby remodeling of signaling and gene regulatory networks permits a drug-tolerant phenotype. Here, we resolve the scale and kinetics of critical subcellular events following oncogenic kinase inhibition and preceding cell cycle re-entry, using mass spectrometry-based phosphoproteomics and RNA sequencing to capture molecular snapshots within the first minutes, hours, and days of BRAF kinase inhibitor exposure in a human -mutant melanoma model of adaptive therapy resistance. By enriching specific phospho-motifs associated with mitogenic kinase activity, we monitored the dynamics of thousands of growth- and survival-related protein phosphorylation events under oncogenic BRAF inhibition and drug removal.
View Article and Find Full Text PDFOn-chip generation of optical frequency combs using nonlinear ring resonators has enabled numerous applications of combs that were otherwise limited to mode-locked lasers. Nevertheless, on-chip frequency combs have relied predominantly on single-ring resonators. In this study, we experimentally demonstrate the generation of a novel class of frequency combs, the topological frequency combs, in a two-dimensional lattice of hundreds of ring resonators that hosts fabrication-robust topological edge states with linear dispersion.
View Article and Find Full Text PDFArticle Synopsis
- Systemic lupus erythematosus (SLE) significantly affects African American women, who experience more severe symptoms and higher mortality rates compared to women of other races, with health disparities linked to socioeconomic factors.
- The role of racism, described as an unmeasured factor affecting health outcomes, has become more recognized in relation to SLE, highlighting the need for addressing structural injustices in healthcare.
- A framework for individual and national actions is proposed to tackle these disparities, advocating for healthcare as a fundamental human right and suggesting collaborative efforts to mitigate the impact of racism in healthcare access and treatment.