Social rank affects the endocrine response to frequent regroupings in grazing dairy heifers.

The objectives of this study were to determine the social behavior response to repeated social regrouping (SR), and if social rank and the changes of social rank affect the growth rate and some metabolites and hormones linked to energy status, in "resident" replacement dairy heifers subjected to SR for 205 d. Fourteen dairy heifers (153.3 ± 16.

Optimizing and developing a scalable, chemically defined, animal component-free lentiviral vector production process in a fixed-bed bioreactor.

Lentiviral vectors (LVVs) play a critical role in gene delivery for gene-modified cell therapies. However, the lack of scalable LVV production methods and the high cost associated with them may limit their use. In this work, we demonstrate the optimization and development of a scalable, chemically defined, animal component-free LVV production process using adherent human embryonic kidney 293T cells in a fixed-bed bioreactor.

Frequent social regroupings affect corporal and reproductive development, metabolic status, and behavioral time budget in dairy heifers.

We aimed to evaluate the corporal and reproductive development, metabolic status, and behavioral patterns of resident dairy heifers subjected to social regroupings (SR). Holstein replacement heifers (153.3 ± 16.

Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), play an oncogenic role in chronic myeloid leukemia by stabilizing nuclear factor-kappa B.

Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 have revolutionized therapy for chronic myeloid leukemia (CML), paving the way for clinical development in other diseases. Despite success, targeting leukemic stem cells and overcoming drug resistance remain challenges for curative cancer therapy. To identify drivers of kinase-independent TKI resistance in CML, we performed genome-wide expression analyses on TKI-resistant versus sensitive CML cell lines, revealing a nuclear factor-kappa B (NF-κB) expression signature.