Publications by authors named "C Fernandez-Becerra"
Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Front Cell Infect Microbiol
November 2024
Article Synopsis
- Extracellular vesicles (EVs) from virus-infected cells could aid in vaccine development by encapsulating viral peptides and indicating tissue changes in infections.
- Blood samples from severe COVID-19 patients, mild cases, and uninfected healthcare workers were collected to analyze the molecular characteristics of EVs and identify suitable vaccine peptides.
- Despite the expectation to find viral peptides, the proteomic analysis revealed no such findings, but highlighted a diverse EV cargo linked to inflammation and viral replication, suggesting EVs play a significant role in COVID-19 pathology.
Parasitic diseases constitute a major global health problem, affecting millions of people worldwide. Recent advances in the study of extracellular vesicles (EVs) have opened up new strategies for biomarker discovery in protozoan and helminth infections. Analyses of EVs in cultures and biological fluids have identified numerous potential biomarkers that could be useful for early and differential diagnosis, monitoring therapeutic responses, and the overall management and control of these diseases.
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- Parasites cause many neglected tropical diseases, affecting over a billion people and leading to millions of deaths each year.
- Recent research shows that tiny particles called extracellular vesicles (EVs) from these parasites help them survive by interacting with host cells and spreading drug resistance.
- The paper suggests better methods to study these EVs, including how to collect and understand them from infected people and animals, and talks about different tests that can be done in host cells.
Recent studies indicate that human spleen contains over 95% of the total parasite biomass during chronic asymptomatic infections caused by . Previous studies have demonstrated that extracellular vesicles (EVs) secreted from infected reticulocytes facilitate binding to human spleen fibroblasts (hSFs) and identified parasite genes whose expression was dependent on an intact spleen. Here, we characterize the spleen-dependent hypothetical gene (PVX_114580).
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