Incidence of enamel defects on permanent canine teeth following extraction of linguoverted mandibular deciduous canine teeth in dogs.

Interceptive orthodontics may be indicated in puppies exhibiting dental malocclusion with linguoverted deciduous mandibular canine teeth to alleviate pain and prevent teeth interlock, which may affect growth and development of the mandibles. Historically extraction of deciduous mandibular canine teeth has been recommended as soon as a malocclusion is identified, often as early as 6-8 weeks of age and no later than 12 weeks of age. This early surgical intervention of deciduous teeth extractions risks potential damage to the developing permanent canine teeth resulting in enamel defects often referred to as a Turner's tooth or Turner's hypoplasia.

Possible improvements in human ovarian grafting by various host and graft treatments.

Background: Anticancer treatment poses a high risk of ovarian failure. In many cases cryopreservation of ovarian tissue is the only option for fertility preservation. Although autologous transplantation of cryopreserved-thawed ovarian tissue has resulted in live births, slow graft revascularization and ischemia after transplantation leads to substantial follicular loss.

Alginate scaffold for organ culture of cryopreserved-thawed human ovarian cortical follicles.

Purpose: To compare macroporous alginate scaffolds with Matrigel for culturing frozen-thawed human primordial follicles in organ culture.

Methods: Twelve girls/women donated ovarian tissue. One tissue sample was fixed immediately after thawing (uncultured samples).

Growth differentiating factor 9 (GDF9) and bone morphogenetic protein 15 both activate development of human primordial follicles in vitro, with seemingly more beneficial effects of GDF9.

Context: The signals initiating growth of primordial follicles are unknown. Bone morphogenetic protein 15 (BMP15) and growth differentiating factor 9 (GDF9) are promising candidates.

Objective: The objective of the study was to evaluate for the first time the effects of human recombinant BMP15 and human recombinant GDF9 on the in vitro development of human primordial follicles.

Terbinafine pharmacokinetics after single dose oral administration in the dog.

Terbinafine is an allylamine antifungal prescribed for the treatment of mycoses in humans. It is increasingly being used in veterinary patients. The purpose of this study was to evaluate the pharmacokinetic properties of terbinafine in dogs after a single oral dose.