Glutamate pyruvate transaminase null allele (GPT0) in the Navajo.

During genetic linkage studies of retinitis pigmentosa in a Navajo Amerindian family, an apparent null allele of erythrocyte GPT (GPT0) was observed in a man and 2 of his daughters. This is the fourth description of a (GPT0) allele, the first outside of Europe and the first in the Navajo.

Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa.

Five pedigrees (including an expanded version of a previously reported pedigree) exhibited typical autosomal dominant retinitis pigmentosa were analysed for linkage of RP to 29 genetic markers. No significant lod scores resulted. The largest lod score is +1.