Publications by authors named "C F Schanbacher"
From Ca dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLN by correction of aberrant Ca-handling.
Pharmacol Res
January 2025
Article Synopsis
- Impaired calcium (Ca) handling in heart cells is a key feature of heart failure (HF), leading to issues like weakened heart contractions and irregular heartbeats.
- The study used transgenic mice with a mutation affecting a calcium regulator (phospholamban) to understand how defects in calcium cycling contribute to HF, noting that these mice experience severe and fast-progressing heart failure.
- Early treatment aimed at correcting calcium cycling using Raf kinase inhibitor protein (RKIP) was found to delay heart cell damage and improve overall health of the mice, indicating that addressing Ca dynamics early on could be crucial for preventing further complications in heart failure.
Background: Surgeons face numerous choices in selecting sutures for skin closure, with potential adverse effects such as tissue tearing.
Objective: To investigate the influence of needle design and suture gauge on tissue tearing during suturing procedures.
Materials And Methods: The authors tested the tear-through force in Newtons for 3 needle types and 3 suture gauges using an artificial skin model and a professional-grade tensiometer.
Background: Reverse cutting needles are commonly used in cutaneous surgery due to their perceived ease of use. Despite this, there is limited research evaluating the force required to puncture skin using contemporary needles.
Objective: This study aims to compare the puncture forces required for two different needle geometries across various gauge sizes.
Background: Lower extremity surgical sites are at an increased risk of wound infection following Mohs micrographic surgery.
Objective: To evaluate the rate of lower extremity surgical site infections following a 14-day regimen of preoperative 4% chlorhexidine gluconate (CHG) rinses and postoperative wound occlusion for 14 days.
Materials And Methods: Retrospective data were collected from procedures performed by the senior author from January 2022 through June 2023.