Publications by authors named "C F M Menck"
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops.
DNA Repair (Amst)
September 2024
Article Synopsis
- Trypanosoma cruzi, the agent responsible for Chagas disease, exhibits unique biological traits and responds to DNA damage through a specific repair pathway called transcription-coupled nucleotide excision repair (TC-NER).
- When UV light induces DNA lesions, unresolved transcriptional stress can lead to a programmed cell death mechanism that resembles apoptosis.
- The study reveals that the Cockayne Syndrome B protein (CSB) plays a crucial role in this process, as its overexpression increases cell death after UV exposure, while its absence confers resistance, suggesting an ATR-dependent apoptosis-like signaling in T. cruzi.
Glioblastoma (GBM) is a highly aggressive brain tumor associated with poor patient survival. The current standard treatment involves invasive surgery, radiotherapy, and chemotherapy employing temozolomide (TMZ). Resistance to TMZ is, however, a major challenge.
View Article and Find Full Text PDFBackground: Telomeropathies are a group of inherited disorders caused by germline pathogenic variants in genes involved in telomere maintenance, resulting in excessive telomere attrition that affects several tissues, including hematopoiesis. RecQ and RTEL1 helicases contribute to telomere maintenance by unwinding telomeric structures such as G-quadruplexes (G4), preventing replication defects. Germline RTEL1 variants also are etiologic in telomeropathies.
View Article and Find Full Text PDFTemozolomide (TMZ) is the leading therapeutic agent for combating Glioblastoma Multiforme (GBM). Nonetheless, the persistence of chemotherapy-resistant GBM cells remains an ongoing challenge, attributed to various factors, including the translesion synthesis (TLS) mechanism. TLS enables tumor cells to endure genomic damage by utilizing specialized DNA polymerases to bypass DNA lesions.
View Article and Find Full Text PDFPurpose: To assess Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum and correlate with ocular surface changes.
Methods: This cross-sectional study evaluated patients with xeroderma pigmentosum. All patients underwent a comprehensive and standardized interview.