Publications by authors named "C F Lucchinetti"
Article Synopsis
- Crystal-storing histiocytosis (CSH) is a rare condition where abnormal protein crystals accumulate in the body, and when it affects the CNS, it can cause persistent imaging abnormalities.* -
- The study describes one local case of CNS CSH alongside 10 other cases, noting that 9 had brain parenchyma involvement and some cases were linked to conditions like lymphoma.* -
- While CNS CSH is uncommon, comprehensive evaluation for related malignancies is crucial, and treatment focuses on addressing these underlying conditions.*
Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. The highly dynamic nature of MS lesions has made them difficult to study using traditional histopathology due to the specificity of current stains. This requires numerous stains to track and study demyelinating activity in MS.
View Article and Find Full Text PDFBackground: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and axonal damage. In MS, incomplete remyelination results in chronically demyelinated axons and degeneration coinciding with disability. This suggests a failure in the ability to remyelinate in MS, however, the precise underlying mechanisms remain unclear.
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- MOGAD is a rare autoimmune disease linked to demyelination, and this case study focuses on a patient who also had metastatic melanoma.
- The patient, a 52-year-old man, showed high levels of MOG-IgG and had significant MRI findings, which indicated inflammation and demyelination, but no MOG presence in the tumor tissue itself.
- Treatment involved several approaches including steroids and immunotherapy for both MOGAD and melanoma, with tocilizumab ultimately leading to a strong and lasting improvement in his condition, highlighting its potential as a dual treatment option.
Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in the cerebrospinal fluid and presents as meningoencephalomyelitis in the majority of patients. Only few neuropathological reports are available and little is known about the pathogenic mechanisms. We performed a histopathological study of two autopsies and nine CNS biopsies of patients with anti-GFAP autoantibodies and found predominantly a lymphocytic and in one autopsy case a granulomatous inflammatory phenotype.
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