Publications by authors named "C F Leong"
Growing evidence indicates the importance of redox reactions homeostasis, mediated predominantly by reactive oxygen species (ROS) in influencing the development, differentiation, progression, metastasis, programmed cell death, tumor microenvironment, and therapeutic resistance of cancer. Therefore, reviewing the ROS-linked epigenetic changes in cancer is fundamental to understanding the progression and prevention of cancer. We review in depth the molecular mechanisms involved in ROS-mediated epigenetic changes that lead to alteration of gene expression by altering DNA, modifying histones, and remodeling chromatin and noncoding RNA.
View Article and Find Full Text PDFNeural decoding reveals dynamic patterns of visual chunk memory processes.
Brain Res Bull
January 2025
Chunk memory constitutes the basic unit that manages long-term memory and converts it into immediate decision-making processes, it remains unclear how to interpret and organize incoming information to form effective chunk memory. This paper investigates electroencephalography (EEG) patterns from the perspective of time-domain feature extraction using chunk memory in visual statistical learning and combines time-resolved multivariate pattern analysis (MVPA). The GFP and MVPA results revealed that chunk memory processes occurred during specific time windows in the learning phase.
View Article and Find Full Text PDFArticle Synopsis
- Isopropylated phenyl phosphates (IPP) are organophosphate flame retardants used in various products, but their leaching raises toxicity concerns due to limited toxicological studies.
- Using zebrafish embryos, the study found significant biological disruptions, including morphological changes and alterations in dopamine levels, alongside behavioral deficits at low concentrations.
- Further analysis indicated IPP inhibits retinoic acid receptor activity and caused hypermethylation in embryos, with distinct impacts observed in the eyes, revealing changes in genes related to nervous system functions.
Introduction: Inhalation drug delivery can deliver high doses of chemotherapeutic drugs to the lung tumor. This study evaluates the efficacy and the mechanistic pathways of nebulized Cur NPs at various sizes to treat multidrug resistant lung cancer.
Methods And Results: Cur-NPs (30 nm and 200 nm) were nebulized separately onto the multidrug-resistant lung cancer cells (H69AR).
Introduction: Hospitalisations can pose hazards and may not be an appropriate care setting for frail nursing home (NH) residents. Few studies have quantified the extent of NH resident hospitalisations in Singapore, hence we aimed to address this knowledge gap by studying characteristics of unplanned hospitalisations over a 1-year period.
Method: This was a retrospective cohort study of 9922 subsidised residents across 59 NHs in Singapore, with analysis using administrative healthcare data.