Publications by authors named "C F Kuper"
Nuclear factor of activated T cells 5 (NFAT5) is an osmosensitive transcription factor that is well-studied in renal but rarely explored in cardiac diseases. Although the association of Coxsackievirus B3 (CVB3) with viral myocarditis is well-established, the role of NFAT5 in this disease remains largely unexplored. Previous research has demonstrated that NFAT5 restricts CVB3 replication yet is susceptible to cleavage by CVB3 proteases.
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- A group of 24 expert scientists from different places met in 2021 to discuss how to use the right words in studying how substances can affect health.
- They focused on figuring out what's important when looking at lab results from tests done before new medicines are approved.
- The workshop covered many topics, like how to handle different results, compare data, and understand how these findings connect to other study results.
Disruption of the immune system during embryonic brain development by environmental chemicals was proposed as a possible cause of neurodevelopmental disorders. We previously found adverse effects of di-n-octyltin dichloride (DOTC) on maternal and developing immune systems of rats in an extended one-generation reproductive toxicity study according to the OECD 443 test guideline. We hypothesize that the DOTC-induced changes in the immune system can affect neurodevelopment.
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- The evaluation of immune system changes is crucial for assessing the safety and effectiveness of new products, with toxicologic pathologists playing a key role in identifying these changes.
- The rise of immunomodulatory therapies has complicated the evaluation process, making it challenging for pathologists, toxicologists, and regulatory reviewers to assess the relevance and potential adverse effects of immune system alterations.
- The piece discusses the need for a more integrated and adaptable approach to assess the safety of immune system changes, highlighting the limitations of current methods and suggesting improvements for evaluating immunotoxic effects.
Article Synopsis
- NFAT5, an osmosensitive transcription factor, plays a significant role in regulating salt and water balance in the cornea, impacting transparency and susceptibility to blindness.
- In healthy corneas, NFAT5 is primarily found in fibroblasts, but its expression increases in corneal macrophages after perforating injury, contributing to fluid balance.
- The study reveals that NFAT5 normally suppresses corneal edema resorption, suggesting that targeting this factor could offer new treatment options for corneal edema and related blindness.