Publications by authors named "C F Bradish"

Article Synopsis
  • NAFLD is projected to become the leading cause of childhood liver failure in developed countries, with maternal metabolic syndrome (MetS) potentially influencing its development in offspring.
  • Research using a mouse model revealed that exposure to MetS after birth (postnatal) leads to significant liver issues such as steatosis (fatty liver) and fibrosis, while prenatal exposure does not.
  • Key findings highlighted the role of imprinted genes, especially the Zac1 gene, in linking maternal MetS to juvenile NAFLD, suggesting that these genes may be critical in understanding and potentially preventing metabolic diseases.
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The behaviour of a nursing dam influences the development, physiology, and behaviour of her offspring. Maternal behaviours can be modulated both by environmental factors, including diet, and by physical or behavioural characteristics of the offspring. In most studies of the effects of the environment on maternal behaviour, F dams nurse their own F offspring.

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Introduction: Foot deformities are frequent complications in Charcot-Marie-Tooth disease (CMT) patients, often requiring orthopedic surgery. However, there are no prospective, randomized studies on surgical management, and there is variation in the approaches among centers both within and between countries.

Methods: In this study we assessed the frequency of foot deformities and surgery among patients recruited into the Inherited Neuropathies Consortium (INC).

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The hip in arthrogryposis.

J Child Orthop

December 2015

Pathology: Hip dislocation is seen in approximately 30 % of children with amyoplasia and approximately 50 % of these will be bilateral.

Treatment: Closed reduction is rarely successful. Open reduction is indicated for unilateral dislocations and for the majority of bilateral dislocations.

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