Analysis of aliphatic and phenolic compounds present in industrial black liquors using HPLC-DAD and IC-MS/MS methods.

Carboxylic acids and aromatic compounds are essential building blocks and starting materials for the production of a wide range of fine chemicals and materials. Their recovery from kraft black liquor, an industrial effluent from pulp and paper mills, is a promising way to produce alternative bio-based chemicals. Reliable methods are needed to identify and quantify the molecules of interest in complex mixtures such as black liquors.

[Development of an evaluation grid for the degree of application of the Montessori method adapted to elderly people in nursing homes].

Despite the growing deployment of the Montessori method in nursing homes, there is no instrument to measure its implementation fidelity, limiting the interpretation of results. Our aims are to i) develop an evaluation grid for the Montessori method in nursing homes; ii) explore its sensitivity to practice heterogeneity among institutions pre-training; and iii) study its sensitivity to change after the training. Based on literature and expert opinions, we created an evaluation grid.

Measuring Indigenous homelessness: Findings from Our Health Counts Toronto.

Objectives: Our Health Counts (OHC) Toronto, an Indigenous population database which addresses gaps in urban health information, was used to measure Thistle's (2017) 12 dimensions of Indigenous homelessness. Using this framework, we examine the sociodemographic characteristics of First Nations, Inuit, and Metis (FNIM) adults living in Toronto, the 12 dimensions as experienced by this population, and the distinctions between FNIM adults who were and those who were not experiencing physical homelessness.

Methods: Respondent-driven sampling (RDS)-II proportions and 95% confidence intervals were produced from the database (n = 915 FNIM adults) to describe key sociodemographic characteristics of the population and to estimate the proportion and number of dimensions of Indigenous homelessness experienced by FNIM adults.

Our Health Counts Toronto: Commercial tobacco use among Indigenous peoples in Toronto.

Objective: Fueled by the commercial tobacco industry, commercial tobacco use continues to be the leading preventable cause of premature death in Canada, with opportunities to improve health outcomes. The objective of this research was to work with Indigenous partners to generate Indigenous population prevalence estimates of commercial tobacco use in Toronto, and examine the association between smoking and sociodemographic, cultural, resiliency, and social variables.

Methods: Respondent-driven sampling (RDS) was used to generate prevalence estimates of commercial tobacco use and potentially associated sociodemographic, cultural, resiliency, and social connection variables for Indigenous adults living in Toronto.

and pharmacological evaluation of GPR65 as a cancer immunotherapy target regulating T-cell functions.

The success of cancer immunotherapies such as immune checkpoint inhibitors, CAR T-cells and immune cell engagers have provided clinicians with tools to bypass some of the limitations of cancer immunity. However, numerous tumour factors curtail the immune response against cancer and limit the efficiency of immuno-oncology (IO) therapies. Acidification of the extra-cellular tumour environment consecutive to aberrant cancer cell metabolism is a well-known promoter of oncogenic processes that also acts as an immune regulator.