Publications by authors named "C Estellat"
Background: The use of generic drugs is a way for healthcare systems to reduce costs, particularly in ambulatory care. Several studies suggest that the prescriber's speciality is associated with the use of generic drugs, and that substitutable drugs prescribed by General Practitioners (GPs) are more often generic, but this association has never been studied in France. In the French legislative context, except in rare situations, all substitutable drugs prescribed should be dispensed in generic form.
View Article and Find Full Text PDFMaternal social deprivation and preterm birth: The PreCARE cohort study.
Paediatr Perinat Epidemiol
January 2025
Background: Maternal exposure to unfavourable social conditions is associated with a higher rate of perinatal complications, such as placental vascular pathologies. A higher risk of preterm birth (PTB) has also been reported, and variations across studies and settings suggest that different patterns may be involved in this association.
Objective: To assess the association between maternal social deprivation and PTB (overall and by phenotype).
Objective: To establish normal current values of various biochemical parameters during pregnancy in the northern area of Paris (France) in a subgroup from the PreCARE cohort and to study their changes according to the term of pregnancy, and to determine the influence of maternal precarity.
Design: The PreCAREbio cohort of pregnant women was defined in the PreCARE study, a multicenter cohort study.
Setting: Participants completed detailed questionnaires at enrolment and immediately postpartum.
Article Synopsis
- Patients with severe eosinophilic asthma often switch from one biologic treatment to another when their current medication isn't effective, but it's unclear whether switching to a different class (anti-IL-4R) or another drug in the same class (anti-IL-5/5R) is better.
- In a study using data from a large asthma cohort, researchers compared the outcomes of patients who switched to either anti-IL-4R mAb or a different anti-IL-5/5R after not responding to their initial treatment.
- Results showed no significant difference in asthma control improvement at six months, but the anti-IL-4R group had a more notable reduction in corticosteroid use, suggesting it might
Article Synopsis
- The study analyzes the use of the French National Health Data System (SNDS), which provides healthcare data for nearly the entire population of France, focusing on the trends in pharmacoepidemiological research based on this data.
- A systematic review of articles from 2012 to 2018 revealed an upward trend in published studies, with the majority focusing on drug utilization, safety, and effectiveness, and a notable concentration on medications for the nervous and cardiovascular systems.
- The findings suggest that while the SNDS is increasingly valuable for drug safety research, there is a need for more studies involving specific populations such as children, pregnant women, and the elderly, who are usually not represented in clinical trials.