Publications by authors named "C Ekenberg"
Post-Transplantation Seroprotection Rates in Liver, Lung, and Heart Transplant Recipients Vaccinated Pre-Transplantation against Hepatitis B Virus and Invasive Pneumococcal Disease.
Vaccines (Basel)
September 2024
Article Synopsis
- Vaccination before solid organ transplantation (SOT) is essential because immunosuppression post-transplant affects vaccine responses, but not much is known about how effective these vaccines are afterward.
- In a study of 136 SOT recipients, only 27.9% showed protection against hepatitis B virus (HBV) and 42.6% against invasive pneumococcal disease (IPD) after transplantation despite being vaccinated before the procedure.
- Patients who had seroprotection when listed for transplantation were significantly less likely to have a non-response to both HBV and IPD, indicating that early vaccination is crucial for improving post-transplant outcomes.
Objectives: Improved survival after hematopoietic cell transplantation (HCT) and an increasingly comorbid transplant population may give rise to new trends in the causes of death.
Methods: This study includes all adult allogeneic HCT recipients transplanted at Rigshospitalet between January 1, 2010 and December 31, 2019. Underlying causes of death were determined using the Classification of Death Causes after Transplantation (CLASS) method.
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus (PTDM) among solid organ transplant (SOT) patients. Using non-genetic risk scores alone; and the combination with PRS, separate logistic regression models were built and compared using receiver operator curves.
View Article and Find Full Text PDFVaccination is an evidence-based strategy to prevent or reduce the severity of infectious diseases (ID). Here, we aimed to describe the experience of implementing a vaccination clinic specifically targeting liver, heart, lung, and combined dual organ transplantation at a single transplantation center in Denmark. In this cohort of 242 solid organ transplant (SOT) candidates, we investigated seroprotection and the proportion of recommended vaccinations documented before transplantation.
View Article and Find Full Text PDFObjective: Human leucocyte antigen (HLA) class I alleles are the main host genetic factors involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has proven a significant challenge in association studies. We assessed how accounting for binding affinities of HLA class I alleles to HIV-1 peptides facilitate association testing of HLA with HIV-1 VL in a heterogeneous cohort.
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