Moving forward-the 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors and beyond: implications and suggestions for laboratories.

The 2019 ASCCP Risk Based Management Consensus Guidelines for prevention of cervical cancer promote clinical management recommendations aligned with our increased understanding of HPV biology and cervical carcinogenesis. They employ HPV-based testing as the basis for risk estimation, allow for personalized risk-based management by incorporating knowledge of current results with prior results, and streamline incorporation of new test methods as they are validated. They continue to support the principles of "equal management for equal risk" and "balancing harms and benefits" adopted in the 2012 version of the guidelines.

Reactivity of an NHC-stabilized pyramidal hydrosilylene with electrophilic boron sources.

Silylenes have become an indispensable tool for molecular bond activation. Their use for the construction of silicon-boron bonds is uncommon in comparison to the numerous studies on silylene-derived silicon-element bond formations. Herein we investigate the reactivity of the pyramidal NHC-coordinated hydrosilylene tBu3SiSi(H)LMe4 (1; NHC = N-heterocyclic carbene, LMe4 = 1,3,4,5-tetramethylimidazolin-2-ylidene) with various boron-centered electrophiles.

Detection of and with the cobas CT/NG v2.0 test: performance compared with the BD ProbeTec CT Q and GC Q amplified DNA and Aptima AC2 assays.

Objectives: Infections due to (CT) and (NG) are among the most common bacterial sexually transmitted infections worldwide, most of which are asymptomatic. Detection of infection using a variety of specimen types in symptomatic and asymptomatic subjects is important to effectively combat CT/NG infections. The performance of the cobas CT/NG v2.

Systematic Study of N-Heterocyclic Carbene Coordinate Hydrosilylene Transition-Metal Complexes.

An in-depth study of the synthesis and structures of N-heterocyclic carbene (NHC)-stabilized silylene transition-metal complexes is reported. An iron hydrosilylene complex, [tBuSi(NHC)(H)Si:→Fe(CO)] (2), was synthesized starting from the corresponding hydrosilylene [tBuSi(NHC)(H)Si:] (1). Complex 2 was fully characterized, including X-ray diffraction analysis, which showed an unusual long Si-Fe bond length.

Phosphinosilylenes as a novel ligand system for heterobimetallic complexes.

A dihydrophosphinosilylene iron complex [LSi{Fe(CO)4}PH2] has been prepared and utilized in the synthesis of novel heterobimetallic complexes. The phosphine moiety in this phosphinosilylene complex allows coordination towards tungsten leading to the iron-tungsten heterobimetallic complex [LSi{Fe(CO)4}PH2{W(CO)5}]. In contrast, the reaction of [LSi{Fe(CO)4}PH2] with ethylenebis(triphenylphosphine)platinum(0) results in the formation of the iron-platinum heterobimetallic complex [LSi{Fe(CO)4}PH{PtH(PPh3)2}] via oxidative addition.