Publications by authors named "C Ehrhardt"
The protein deacetylase HDAC6 has been controversially linked to cancer cell proliferation and viral propagation. We analyzed whether a pharmacological depletion of HDAC6 with a recent proteolysis-targeting chimera (PROTAC) kills tumor cells. We show that low micromolar doses of the cereblon-based PROTAC TH170, but not its inactive analog TH170E, induce proteasomal degradation of HDAC6.
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- Sudden unexpected infant death (SUID), primarily from sudden infant death syndrome (SIDS), is a major cause of infant mortality, but there has been no focused study on SIDS content on YouTube despite its prevalence on platforms like Instagram and Twitter.
- This observational study, conducted between December 2023 and January 2024, analyzed the top 100 SIDS-related videos on YouTube, identifying that most were produced by organizations, with a strong emphasis on risk factors and prevention measures.
- The findings suggest the need for enhanced clinical and public health strategies to better utilize digital content to address SIDS risk factors and promote awareness, especially outside the United States, to ultimately reduce infant mortality rates worldwide.
The activity of a Ga(III) catecholate complex against Aspergillus fumigatus in conditions mimicking cystic fibrosis lung and inhaled formulations for its pulmonary administration.
Brunella Grassiri Semih Esin Magdalena E Piatek Lewis More O'Ferrall Johannes A Sake Carsten Ehrhardt
Int J Pharm
December 2024
Azole-resistant Aspergillus fumigatus (A. fumigatus) is an emerging worldwide pathogen. Pulmonary aspergillosis primarily affects severely immunocompromised patients and is also a particularly critical condition for cystic fibrosis (CF) patients.
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