Publications by authors named "C Edmondson"
Article Synopsis
- Neutrophils play a significant role in chronic lung inflammation in cystic fibrosis (CF), but their blood markers are rarely studied; the neutrophil-to-lymphocyte ratio (NLR) is a potential but underexplored biomarker.
- This study examined NLR in children with CF, linking it to clinical states like stable conditions and acute pulmonary exacerbations, using data collected from 2016-2021.
- Results showed that NLR increased significantly during acute exacerbations compared to stable states, particularly in females and older children, although it did not correlate with lung function, suggesting it may help track inflammation over time.
The COVID-19 pandemic necessitated a rapid shift in clinical research to perform virtual visits and remote endpoint assessments, providing a key opportunity to optimize the use of remote endpoints for clinical trials in cystic fibrosis. The use of remote endpoints could allow more diverse participation in clinical trials while minimizing participant burden but must be robustly evaluated to ensure adequate performance and feasibility. In response, the Cystic Fibrosis Foundation convened the Remote Endpoint Task Force (Supplemental Table 1), a multidisciplinary group of CF researchers with remote endpoint expertise and community members tasked to better understand the current and future use of remote endpoints for clinical research.
View Article and Find Full Text PDF(1) Background: The purpose of this study was to evaluate the time toxicity, or time spent in health care, of immunotherapy- versus chemotherapy-based regimens for metastatic esophageal and gastric cancers. (2) Methods: A literature search was conducted, and 18 phase III clinical trials of immune checkpoint inhibitors were selected for analysis. Health care days were calculated based on the number of days associated with receiving therapy and the adverse events reported in the clinical trials.
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- Handheld spirometry allows for at-home monitoring of lung function, which became particularly important during the COVID-19 pandemic, but its accuracy compared to clinic-based spirometry in children remains uncertain.
- A study analyzed paired forced expiratory volume (FEV) readings from 67 participants aged 6 years and older, revealing that home spirometry often produced lower results and had moderate variability during periods of clinical stability.
- The findings suggest that home spirometry cannot replace clinic spirometry in children, especially as new handheld devices may underread results, indicating the need for dual measurements in clinical settings to improve the accuracy of home data trends.
Carpal tunnel syndrome (CTS) is a common entrapment neuropathy characterized by pain, numbness, and impaired function of the hand due to compression of the median nerve at the level of the wrist. Although CTS can develop from repetitive strain, injury, or medical conditions, there are also congenital and genetic risk factors that can predispose individuals to the condition. With respect to anatomical factors, some individuals are born with a smaller carpal tunnel, which increases their susceptibility to median nerve compression.
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