Publications by authors named "C Edelsten"

Background: Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening to enable local eye care professionals (ECPs), who carry the main burden, to screen children with JIA appropriately and with confidence.

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Background: Childhood onset uveitis comprises a group of rare inflammatory disorders characterized by clinical heterogeneity, chronicity, and uncertainties around long term outcomes. Standardized, detailed datasets with harmonized clinical definitions and terminology are needed to enable the clinical research necessary to stratify disease phenotype and interrogate the putative determinants of health outcomes. We aimed to develop a core routine clinical collection dataset for clinicians managing children with uveitis, suitable for multicenter and national clinical and experimental research initiatives.

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Article Synopsis
  • The Multinational Interdisciplinary Working Group for Uveitis in Childhood aimed to update guidelines for treating children with juvenile idiopathic arthritis-associated uveitis (JIAU) and idiopathic chronic anterior uveitis (CAU).
  • A systematic literature review covering studies from December 2014 to June 2020 was conducted by pediatric rheumatologists and ophthalmologists to gather evidence for the new recommendations.
  • The update resulted in 14 treatment recommendations for JIAU and CAU, achieving over 90% consensus among experts, to guide clinicians in effectively managing these conditions in children.
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Objective: Children with juvenile idiopathic arthritis (JIA) need regular examinations for uveitis to avoid visual morbidity from the most common extraarticular manifestation of disease. This study was undertaken to investigate the feasibility, acceptability, and performance of optical coherence tomography (OCT) imaging-based diagnosis of uveitis.

Methods: This observational cross-sectional study included children with and those without uveitis.

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