Publications by authors named "C E Wyers"
X-linked osteoporosis, caused by PLS3 genetic variants, is a rare bone disease, clinically affecting mainly men. Limited data are available on bone microarchitecture and genotype-phenotype correlations in this disease. Our aims were to assess bone microarchitecture and strength in adults with PLS3 variants using high-resolution peripheral quantitative computed tomography (HR-pQCT) and to explore differences in the phenotype from HR-pQCT between PLS3 variants.
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- Abdominal aortic calcification (AAC) was found in 27.6% of patients attending a Fracture Liaison Service, with varying levels of severity among them.
- The study indicated that age, body mass index (BMI), smoking, and history of cardiovascular disease (CVD) were risk factors for AAC, while the location of fractures and bone mineral density (BMD) were not related to AAC levels.
- In patients without CVD, prevalent vertebral fractures were linked to the presence of AAC but not to its severity, suggesting the complexity of factors influencing AAC in fracture patients.
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- Shared decision making (SDM) is designed to enhance patient experiences and treatment results, but its effectiveness in patients needing anti-osteoporosis medication (AOM) following a fracture is uncertain.
- This study evaluated a multi-component adherence intervention (MCAI), which included a patient decision aid and motivational interviewing, against usual care (UC) to measure outcomes like AOM persistence, initiation, and adherence over a year.
- While AOM persistence and other secondary outcomes showed no significant differences between MCAI and UC, the MCAI group had a notably better SDM process score, indicating improved patient engagement, particularly for those with better health literacy.
Article Synopsis
- Androgen Deprivation Therapy (ADT) for prostate cancer significantly increases long-term fracture risk, particularly within the first six months of starting treatment.
- A study of 471 men revealed that those currently using ADT had a much higher likelihood of experiencing fragility fractures compared to those who never used it.
- The findings highlight the need for preventive measures against fragile fractures at the beginning of ADT to manage this increased risk effectively.