Publications by authors named "C E Whiteman"
Article Synopsis
- - The PUMAS project aims to address the lack of representation of African and Latin American populations in psychiatric genetics studies by analyzing genetic data from individuals with serious mental illness (SMI), including disorders like schizophrenia and bipolar disorder, using data from 89,320 participants across four different cohorts.
- - The research involves harmonizing data from various clinical assessments to create standardized measures of mental health symptoms, which allows for more accurate genetic analyses across different diagnoses and symptoms.
- - The findings show that schizophrenia and severe bipolar disorder are the most common diagnoses among participants, and a set of 19 key symptoms has been identified, which may be useful for cross-diagnosis genetic studies.
Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome. These clocks are widely used to measure the age of tissues and cells. The discrepancy between epigenetic age (EpiAge), as estimated by these clocks, and chronological age is referred to as EpiAge acceleration.
View Article and Find Full Text PDFBackground And Purpose: Pregnancy-associated vascular remodelling is essential for both maternal and fetal health. We have previously shown that maternal endothelial cell tetrahydrobiopterin (BH4) deficiency causes poor pregnancy outcomes. Here, we investigated the role and mechanisms of endothelial cell-mediated vasorelaxation function in these outcomes.
View Article and Find Full Text PDFMalignancy of the sphenoid sinus is rare. Tumors may extend to adjacent anatomic structures before detection and may be easily missed. Outcomes are typically poor and vary by tumor type.
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