: refined taxonomy and new insights into the biology and evolution of diatom-infecting DNA viruses.

Bacilladnaviruses are single-stranded DNA viruses that infect diatoms that, so far, have been primarily identified in marine organisms and environments. Using a viral metagenomics approach, we discovered 13 novel bacilladnaviruses originating from samples of mud-flat snail (; =3 genomes) and benthic sediments (=10 genomes) collected from the Avon-Heathcote Estuary in New Zealand. Comparative genomics and phylogenetic analysis of the new bacilladnavirus sequences in the context of the previously classified members of the family helped refine and further expand the taxonomy.

Independent Risk Factors for Less Than "Top Box" Doctor Communication Patient Experience Survey Scores in an Urban Teaching Hospital.

This study explored the independent risk factors for patients giving a less than "top box" score on their Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys in the "doctor communication" domain (DCD). After adjusting for age, gender, length of stay, receiving a postdischarge phone call (PC), new medication during hospitalization, highest education level, language spoken at home, and zip code, results from 803 HCAHPS surveys (from January 1 to December 31, 2023) revealed that not receiving a PC was associated with a more than doubling of the odds that a patient would give less than a "top box" score for the DCD (overall adjusted odds ratio of 2.22; 95% confidence interval: 1.

5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers.

Nucleobase analogue (NBA) drugs, such as 5-fluorouracil (5-FU), are effective chemotherapeutics, but their clinical use is limited by severe side effects. Compelling evidence suggests that the use of S-methyl-5'-thioadenosine (MTA) can selectively reduce NBA toxicity on normal tissues while maintaining the efficacy of NBAs on methylthioadenosine phosphorylase (MTAP)-deficient cancers. However, we found that MTA induced hypothermia at its effective dose, limiting its translational potential.

Natural Language Processing Technologies for Public Health in Africa: Scoping Review.

Background: Natural language processing (NLP) has the potential to promote public health. However, applying these technologies in African health systems faces challenges, including limited digital and computational resources to support the continent's diverse languages and needs.

Objective: This scoping review maps the evidence on NLP technologies for public health in Africa, addressing the following research questions: (1) What public health needs are being addressed by NLP technologies in Africa, and what unmet needs remain? (2) What factors influence the availability of public health NLP technologies across African countries and languages? (3) What stages of deployment have these technologies reached, and to what extent have they been integrated into health systems? (4) What measurable impact has these technologies had on public health outcomes, where such data are available? (5) What recommendations have been proposed to enhance the quality, cost, and accessibility of health-related NLP technologies in Africa?

Methods: This scoping review includes academic studies published between January 1, 2013, and October 3, 2024.

Early-stage investigators' experiences with an National Institutes of Health Pilot Award Program.

Background: Academic-community research partnerships focusing on addressing the social determinants of health and reducing health disparities have grown substantially in the last three decades. Early-stage investigators (ESIs), however, are less likely to receive grant funding from organizations like the National Institutes of Health, and we know little about the facilitators and barriers they face on their career journeys or the best ways to support them and their community research partnerships. This study examines ESIs' experiences with a program that funded and supported their community-partnered pilot health disparities research.