Publications by authors named "C E Uhlig"
Introduction: To investigate the long-term outcomes of emergency penetrating keratoplasty using cryopreserved human donor corneas in the management of actual or imminent corneal perforation.
Methods: A retrospective analysis was performed of the treatment efficacy of emergency penetrating keratoplasty using a cryopreserved human donor cornea, in 14 eyes of 14 patients with corneal ulcers of different etiology. For comparison, the medical histories of 14 patients who had undergone penetrating keratoplasty with the same indication, but received a regularly processed human corneal graft, were retrospectively analyzed.
Article Synopsis
- AICA ribosiduria is a rare disorder linked to developmental delays, seizures, and vision issues, caused by mutations in the ATIC gene.
- A teenage patient showed two specific mutations in ATIC, including one that had not been reported before.
- A purine-enriched diet reduced harmful substances in the body, suggesting that dietary changes could be a potential treatment for this condition.
Article Synopsis
- The study focuses on understanding severe COVID-19 disease progression by analyzing the blood plasma of patients to identify specific serologic markers that could predict worsening symptoms like inflammation and blood clotting.
- Through extensive testing on seven critically ill patients, researchers used a statistical model to identify proteins that signal imminent increases in inflammatory responses and coagulopathy around 24-48 hours before they occur.
- The findings highlight the potential of certain proteins, which are involved in biological processes like inflammation and coagulation, to serve as predictive biomarkers for severe COVID-19, but further validation is needed to confirm their effectiveness.
Lipofuscin (LF) accumulates during lifetime in the retinal pigment epithelium (RPE) and is thought to play a crucial role in intermediate and late age-related macular degeneration (AMD). In an attemt to simulate aged retina and to study response of retinal microglia and RPE cells to LF, we injected a suspension of LF into the subretinal space of adult mice. LF suspension was obtained from human donor eyes.
View Article and Find Full Text PDFFood fraud, even when not in the news, is ubiquitous and demands the development of innovative strategies to combat it. A new non-targeted method (NTM) for distinguishing spelt and wheat is described, which aids in food fraud detection and authenticity testing. A highly resolved fingerprint in the form of spectra is obtained for several cultivars of spelt and wheat using liquid chromatography coupled high-resolution mass spectrometry (LC-HRMS).
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