Publications by authors named "C E Tatsui"
Study Design: Narrative Review.
Objective: The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental instrumentation to maintain long-term spinal stability.
Purpose: The Prognostic Index for Spinal Metastasis (PRISM) is a scoring system derived from prospective data from a single institution that stratifies patients undergoing spine stereotactic radiosurgery (SSRS) for spinal metastases into subgroups by overall (OS). We sought to further demonstrate its generalizability by performing validation with a large dataset from a second high-volume institution, Mayo Clinic.
Methods And Materials: Eight hundred seventy-nine patients-424 from Mayo Clinic and 455 from MD Anderson Cancer Center (MDACC)-who received SSRS between 2007 and 2019 were identified.
Article Synopsis
- sLITT is a minimally invasive treatment for metastatic epidural spinal cord compression, offering benefits over traditional surgery.
- A study analyzed outcomes for 129 patients who underwent sLITT, finding a one-year freedom from local failure rate of 80% and overall survival rate of 78%.
- Key factors affecting treatment success included the location of the disease and post-treatment imaging scores, highlighting the importance of early treatment responses as potential prognostic markers.
Study Design: Survey study.
Objectives: The purpose of this study was to characterize the utility of 3D printed patient specific anatomic models for the planning of complex primary spine tumor surgeries.
Methods: A survey of individual members of an international study group of spinal oncology surgeons was performed.
Article Synopsis
- Spontaneous activity in dorsal root ganglion (DRG) neurons is a major factor in neuropathic pain, which often goes untreated.
- Researchers found that the drug tomivosertib (eFT508) can suppress this spontaneous activity in human sensory neurons known as nociceptors by inhibiting a specific signaling pathway (MNK) within minutes.
- The treatment not only reduced the activity of these neurons but also led to key changes in their electrical properties, indicating potential mechanisms that could be targeted in future clinical trials for managing neuropathic pain.