Publications by authors named "C E Sunkel"
Article Synopsis
- The study investigates sex differences in podocyte cells, which are key for kidney function, particularly how these differences manifest under normal and stressed conditions caused by mTOR inhibition.
- Using a specialized mouse model, researchers isolated podocytes and performed RNA sequencing, proteomics, and metabolomics to uncover distinct molecular signatures tied to biological sex.
- Results showed significant sex-specific variations in gene expression and protein levels, with mTOR inhibition affecting male podocyte responses more prominently, highlighting potential transcription factors that govern these differences.
Article Synopsis
- Faithful cell division depends on the correct attachment of kinetochores to microtubules that pull chromosomes apart, and errors can occur during mitosis.
- Proteins like AURORA B and AURORA A help to destabilize incorrect attachments, while MPS1 also plays a role in weakening the connections between kinetochores and microtubules, ensuring proper alignment.
- The study reveals that MPS1 activates AURORA A kinase (AAK) at centrosomes to facilitate error correction, demonstrating a communication pathway that helps maintain chromosome integrity during cell division.
Background: Efforts to understand the mechanisms and consequences of mental health-related stigma and discrimination need to center the perspectives of people affected by these negative impacts, through research efforts that are led or co-led by people with lived experience (PWLE) of mental health conditions.
Methods: This study used co-production principles to explore global perspectives of stigma and discrimination among people meeting the inclusion criteria of identifying as PWLEs and being willing to share their experiences of stigma and discrimination resulting from a diagnosis of a mental health condition, and who had also participated in anti-stigma activities. Participants were recruited online via a self-selecting snowball sampling method.