Publications by authors named "C E Stamper"
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor-matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor dependent with distinct tissue compartmentalization patterns and adaptations: Intestinal CD103 resident MAIT cells presented an immunoregulatory CD39CD27 profile, whereas MAIT cells expressing NCAM1/CD56 dominated in the liver and exhibited enhanced effector capacity with elevated response magnitude and polyfunctionality.
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- The study presents neutron-scattering measurements of the density of states (DOS) for water and liquid Fomblin across a range of temperatures, revealing a consistent low-energy linear scaling of the DOS that holds at all temperatures.
- A notable sharp transition at the melting point of water is observed, where the low-frequency DOS shifts to align with Debye's law, while Fomblin displays a smooth change between two behaviors indicative of its glassy dynamics.
- Both materials show that the slope a(T) of the DOS increases with temperature in an exponential Arrhenius-like manner, a finding supported by molecular dynamics simulations and consistent with the predictions of instantaneous normal mode (INM) theory.
Recent microbiome research has incorporated a higher number of samples through more participants in a study, longitudinal studies, and metanalysis between studies. Physical limitations in a sequencing machine can result in samples spread across sequencing runs. Here we present the results of sequencing nearly 1000 16S rRNA gene sequences in fecal (stabilized and swab) and oral (swab) samples from multiple human microbiome studies and positive controls that were conducted with identical standard operating procedures.
View Article and Find Full Text PDFObesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, including a role for brain serotonergic systems in the relationship between HFD and anxiety. Evidence suggests the gut microbiome and the serotonergic brain system together may play an important role in this response.
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- Stromal cells are crucial for maintaining the balance of epithelial and immune cells and are significant in the development of inflammatory bowel disease (IBD).
- The research investigates the stromal response to inflammation in pediatric IBD, identifying specific inflammatory reactions in different parts of the colon and intestinal layers.
- Findings show that certain fibroblasts and monocytes/macrophages interact closely in the intestine, with fibroblasts promoting the conversion of monocytes into a specific type of macrophage that resembles those found in young IBD patients, indicating the stroma's role in guiding macrophage development.